scREAD A Single-cell RNA-Seq Database for Alzheimer's Disease
General information
Overview

scREAD Data ID: AD00110

Species: Human

Region: Prefrontal cortex

Condition: Disease

Braak stage: 1, 4 - 5

Gender: Female

Age: 77-90+ years

Datasets from the same experiment
Dataset information

Number of AD associated cells: 15300

Number of control-like cells: 2651

Number of identified cell types: 7

Dataset source:

Title: Human_and_Mouse Single-Nucleus Transcriptomics Reveal TREM2-dependent_and_TREM2-independent Cellular Responses in Alzheimer's Disease

Methodology: Single-nucleus RNA-seq

Protocol: 10x Genomics

GEO/synapse number: syn21125841

Pubmed ID: 31932797

Citation: Zhou Y, Song WM, Andhey PS, Swain A et al. Human_and_mouse single-nucleus transcriptomics reveal TREM2-dependent_and_TREM2-independent cellular responses in Alzheimer’s disease. Nat Med 2020 Jan;26(1):131-142.

Cell clustering

Cell type & subcluster:

Gene expression

Point size:

4
Differential expression (DE) / Gene set enrichment

Group:

Find differentially expressed genes in each cell type by comparing it to all of the others.

Cell type of interest:

Log2 fold-change cutoff:

0.5

Adjusted p-value cutoff:

10^-6
10^-5
10^-4
10^-3
0.01
0.05
0.1
1
DE direction:
SLC1A2 2.87611 0.891 0.278 0.00e+0
ATP1A2 2.50032 0.845 0.153 0.00e+0
ADGRV1 2.47457 0.713 0.093 0.00e+0
AQP4 2.46597 0.756 0.108 0.00e+0
GJA1 2.34641 0.686 0.06 0.00e+0
GFAP 2.29681 0.848 0.129 0.00e+0
GLUL 2.10638 0.857 0.32 0.00e+0
COL5A3 2.04411 0.597 0.07 0.00e+0
AHNAK 2.03573 0.705 0.047 0.00e+0
ATP1B2 2.00043 0.71 0.159 0.00e+0
SLC25A18 1.92909 0.64 0.052 0.00e+0
CST3 1.92787 0.813 0.254 0.00e+0
TPD52L1 1.89208 0.612 0.075 0.00e+0
HIF3A 1.83805 0.666 0.068 0.00e+0
SLC14A1 1.79017 0.521 0.013 0.00e+0