Details - scREAD

General information

Overview

scREAD Data ID: AD00107

Species: Human

Region: Prefrontal cortex

Condition: Disease

Braak stage: 3, 5

Gender: Male

Age: 77-90+ years

Datasets from the same experiment

AD00101 | AD00106 | AD00107 | AD00108 | AD00109 | AD00110 |

Dataset information

Number of AD associated cells: 16954

Number of control-like cells: 1856

Number of identified cell types: 7

Dataset source:

Title: Human_and_Mouse Single-Nucleus Transcriptomics Reveal TREM2-dependent_and_TREM2-independent Cellular Responses in Alzheimer's Disease

Methodology: Single-nucleus RNA-seq

Protocol: 10x Genomics

GEO/synapse number: syn21125841

Pubmed ID: 31932797

Citation: Zhou Y, Song WM, Andhey PS, Swain A et al. Human_and_mouse single-nucleus transcriptomics reveal TREM2-dependent_and_TREM2-independent cellular responses in Alzheimer’s disease. Nat Med 2020 Jan;26(1):131-142.

Cell clustering

Cell type & subcluster:

Gene expression

Point size:

4

Please enter a gene symbol.

Differential expression (DE) / Gene set enrichment

Group:

Find differentially expressed genes in each cell type by comparing it to all of the others.

Cell type of interest:

Log2 fold-change cutoff:

0.5

Adjusted p-value cutoff:

10^-6

10^-5

10^-4

10^-3

0.01

0.05

0.1

1

DE direction:

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SLC1A2	2.78265	0.946	0.286	0.00e+0
ADGRV1	2.64563	0.928	0.082	0.00e+0
GJA1	2.52543	0.883	0.075	0.00e+0
AQP4	2.47219	0.924	0.119	0.00e+0
COL5A3	2.39793	0.8	0.063	0.00e+0
ATP1A2	2.36339	0.953	0.142	0.00e+0
FGFR3	2.28261	0.828	0.023	0.00e+0
ATP1B2	2.12027	0.858	0.138	0.00e+0
GFAP	2.09995	0.845	0.165	0.00e+0
HIF3A	2.00844	0.839	0.042	0.00e+0
TPD52L1	1.90395	0.778	0.086	0.00e+0
SLC25A18	1.88953	0.823	0.082	0.00e+0
RYR3	1.8884	0.735	0.049	0.00e+0
RANBP3L	1.86872	0.718	0.036	0.00e+0
SLC1A3	1.8576	0.905	0.246	0.00e+0