scREAD A Single-cell RNA-Seq Database for Alzheimer's Disease
General information
Overview

scREAD Data ID: AD00107

Species: Human

Region: Prefrontal cortex

Condition: Disease

Braak stage: 3, 5

Gender: Male

Age: 77-90+ years

Datasets from the same experiment
Dataset information

Number of AD associated cells: 16954

Number of control-like cells: 1856

Number of identified cell types: 7

Dataset source:

Title: Human_and_Mouse Single-Nucleus Transcriptomics Reveal TREM2-dependent_and_TREM2-independent Cellular Responses in Alzheimer's Disease

Methodology: Single-nucleus RNA-seq

Protocol: 10x Genomics

GEO/synapse number: syn21125841

Pubmed ID: 31932797

Citation: Zhou Y, Song WM, Andhey PS, Swain A et al. Human_and_mouse single-nucleus transcriptomics reveal TREM2-dependent_and_TREM2-independent cellular responses in Alzheimer’s disease. Nat Med 2020 Jan;26(1):131-142.

Cell clustering

Cell type & subcluster:

Gene expression

Point size:

4
Differential expression (DE) / Gene set enrichment

Group:

Find differentially expressed genes in each cell type by comparing it to all of the others.

Cell type of interest:

Log2 fold-change cutoff:

0.5

Adjusted p-value cutoff:

10^-6
10^-5
10^-4
10^-3
0.01
0.05
0.1
1
DE direction:
SLC1A2 2.78265 0.946 0.286 0.00e+0
ADGRV1 2.64563 0.928 0.082 0.00e+0
GJA1 2.52543 0.883 0.075 0.00e+0
AQP4 2.47219 0.924 0.119 0.00e+0
COL5A3 2.39793 0.8 0.063 0.00e+0
ATP1A2 2.36339 0.953 0.142 0.00e+0
FGFR3 2.28261 0.828 0.023 0.00e+0
ATP1B2 2.12027 0.858 0.138 0.00e+0
GFAP 2.09995 0.845 0.165 0.00e+0
HIF3A 2.00844 0.839 0.042 0.00e+0
TPD52L1 1.90395 0.778 0.086 0.00e+0
SLC25A18 1.88953 0.823 0.082 0.00e+0
RYR3 1.8884 0.735 0.049 0.00e+0
RANBP3L 1.86872 0.718 0.036 0.00e+0
SLC1A3 1.8576 0.905 0.246 0.00e+0