scREAD A Single-cell RNA-Seq Database for Alzheimer's Disease
General information
Overview

scREAD Data ID: AD00203

Species: Human

Region: Entorhinal Cortex

Condition: Disease

Braak stage: 4 - 5

Gender: Male

Age: mean age 77.6, range 67.3-91 years

Datasets from the same experiment
Dataset information

Number of AD associated cells: 3770

Number of control-like cells: 298

Number of identified cell types: 6

Dataset source:

Title: A Single-Cell Atlas of Entorhinal Cortex From Individuals With Alzheimer's Disease Reveals Cell-Type-Specific Gene Expression Regulation

Methodology: Single-nucleus RNA-seq

Protocol: DroNc-seq

GEO/synapse number: GSE138852

Pubmed ID: 31768052

Citation: Grubman A, Chew G, Ouyang JF, Sun G et al. A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation. Nat Neurosci 2019 Dec;22(12):2087-2097.

Cell clustering

Cell type & subcluster:

ARI score: 0.9642564

Gene expression

Point size:

4
Differential expression (DE) / Gene set enrichment

Group:

Find differentially expressed genes in each cell type by comparing it to all of the others.

Cell type of interest:

Log2 fold-change cutoff:

0.5

Adjusted p-value cutoff:

10^-6
10^-5
10^-4
10^-3
0.01
0.05
0.1
1
DE direction: