scREAD A Single-cell RNA-Seq Database for Alzheimer's Disease
General information
Overview

scREAD Data ID: AD00109

Species: Human

Region: Prefrontal cortex

Condition: Disease

Braak stage: 3, 5

Gender: Female

Age: 77-90+ years

Datasets from the same experiment
Dataset information

Number of AD associated cells: 9891

Number of control-like cells: 2654

Number of identified cell types: 7

Dataset source:

Title: Human_and_Mouse Single-Nucleus Transcriptomics Reveal TREM2-dependent_and_TREM2-independent Cellular Responses in Alzheimer's Disease

Methodology: Single-nucleus RNA-seq

Protocol: 10x Genomics

GEO/synapse number: syn21125841

Pubmed ID: 31932797

Citation: Zhou Y, Song WM, Andhey PS, Swain A et al. Human_and_mouse single-nucleus transcriptomics reveal TREM2-dependent_and_TREM2-independent cellular responses in Alzheimer’s disease. Nat Med 2020 Jan;26(1):131-142.

Cell clustering

Cell type & subcluster:

Gene expression

Point size:

4
Differential expression (DE) / Gene set enrichment

Group:

Find differentially expressed genes in each cell type by comparing it to all of the others.

Cell type of interest:

Log2 fold-change cutoff:

0.5

Adjusted p-value cutoff:

10^-6
10^-5
10^-4
10^-3
0.01
0.05
0.1
1
DE direction:
SLC1A2 2.4945 0.872 0.235 0.00e+0
AQP4 2.23576 0.681 0.107 0.00e+0
ADGRV1 2.16433 0.486 0.065 0.00e+0
GFAP 2.1362 0.93 0.223 0.00e+0
GJA1 2.07911 0.593 0.074 0.00e+0
CLU 1.88916 0.944 0.501 0.00e+0
ATP1B2 1.81486 0.635 0.134 0.00e+0
CST3 1.76712 0.862 0.285 0.00e+0
GLUL 1.73218 0.817 0.303 0.00e+0
ATP1A2 1.71717 0.698 0.157 0.00e+0
DTNA 1.64687 0.658 0.215 0.00e+0
FAM107A 1.64447 0.736 0.151 0.00e+0
COL5A3 1.63251 0.386 0.068 0.00e+0
ITM2C 1.53943 0.633 0.213 0.00e+0
SLC14A1 1.45974 0.347 0.016 0.00e+0