scREAD A Single-cell RNA-Seq Database for Alzheimer's Disease
General information
Overview

scREAD Data ID: AD00108

Species: Human

Region: Prefrontal cortex

Condition: Disease

Braak stage: 3 - 5

Gender: Male

Age: 77-90+ years

Datasets from the same experiment
Dataset information

Number of AD associated cells: 11403

Number of control-like cells: 3704

Number of identified cell types: 7

Dataset source:

Title: Human_and_Mouse Single-Nucleus Transcriptomics Reveal TREM2-dependent_and_TREM2-independent Cellular Responses in Alzheimer's Disease

Methodology: Single-nucleus RNA-seq

Protocol: 10x Genomics

GEO/synapse number: syn21125841

Pubmed ID: 31932797

Citation: Zhou Y, Song WM, Andhey PS, Swain A et al. Human_and_mouse single-nucleus transcriptomics reveal TREM2-dependent_and_TREM2-independent cellular responses in Alzheimer’s disease. Nat Med 2020 Jan;26(1):131-142.

Cell clustering

Cell type & subcluster:

Gene expression

Point size:

4
Differential expression (DE) / Gene set enrichment

Group:

Find differentially expressed genes in each cell type by comparing it to all of the others.

Cell type of interest:

Log2 fold-change cutoff:

0.5

Adjusted p-value cutoff:

10^-6
10^-5
10^-4
10^-3
0.01
0.05
0.1
1
DE direction:
SLC1A2 2.86093 0.978 0.325 0.00e+0
ADGRV1 2.59936 0.935 0.115 0.00e+0
ATP1A2 2.46121 0.975 0.201 0.00e+0
GJA1 2.41141 0.878 0.071 0.00e+0
AQP4 2.3238 0.887 0.126 0.00e+0
ATP1B2 2.27351 0.897 0.166 0.00e+0
COL5A3 2.19993 0.84 0.08 0.00e+0
GLUL 2.1838 0.944 0.291 0.00e+0
SLC25A18 2.0364 0.836 0.065 0.00e+0
FGFR3 2.00915 0.824 0.04 0.00e+0
RYR3 1.9492 0.841 0.083 0.00e+0
SDC4 1.9286 0.745 0.021 0.00e+0
TPD52L1 1.92438 0.786 0.065 0.00e+0
CLU 1.89695 0.973 0.584 0.00e+0
SLC14A1 1.89389 0.69 0.02 0.00e+0