Details - scREAD

General information

Overview

scREAD Data ID: AD00108

Species: Human

Region: Prefrontal cortex

Condition: Disease

Braak stage: 3 - 5

Gender: Male

Age: 77-90+ years

Datasets from the same experiment

AD00101 | AD00106 | AD00107 | AD00108 | AD00109 | AD00110 |

Dataset information

Number of AD associated cells: 11403

Number of control-like cells: 3704

Number of identified cell types: 7

Dataset source:

Title: Human_and_Mouse Single-Nucleus Transcriptomics Reveal TREM2-dependent_and_TREM2-independent Cellular Responses in Alzheimer's Disease

Methodology: Single-nucleus RNA-seq

Protocol: 10x Genomics

GEO/synapse number: syn21125841

Pubmed ID: 31932797

Citation: Zhou Y, Song WM, Andhey PS, Swain A et al. Human_and_mouse single-nucleus transcriptomics reveal TREM2-dependent_and_TREM2-independent cellular responses in Alzheimer’s disease. Nat Med 2020 Jan;26(1):131-142.

Cell clustering

Cell type & subcluster:

Gene expression

Point size:

4

Please enter a gene symbol.

Differential expression (DE) / Gene set enrichment

Group:

Find differentially expressed genes in each cell type by comparing it to all of the others.

Cell type of interest:

Log2 fold-change cutoff:

0.5

Adjusted p-value cutoff:

10^-6

10^-5

10^-4

10^-3

0.01

0.05

0.1

1

DE direction:

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SLC1A2	2.86093	0.978	0.325	0.00e+0
ADGRV1	2.59936	0.935	0.115	0.00e+0
ATP1A2	2.46121	0.975	0.201	0.00e+0
GJA1	2.41141	0.878	0.071	0.00e+0
AQP4	2.3238	0.887	0.126	0.00e+0
ATP1B2	2.27351	0.897	0.166	0.00e+0
COL5A3	2.19993	0.84	0.08	0.00e+0
GLUL	2.1838	0.944	0.291	0.00e+0
SLC25A18	2.0364	0.836	0.065	0.00e+0
FGFR3	2.00915	0.824	0.04	0.00e+0
RYR3	1.9492	0.841	0.083	0.00e+0
SDC4	1.9286	0.745	0.021	0.00e+0
TPD52L1	1.92438	0.786	0.065	0.00e+0
CLU	1.89695	0.973	0.584	0.00e+0
SLC14A1	1.89389	0.69	0.02	0.00e+0