scREAD A Single-cell RNA-Seq Database for Alzheimer's Disease
General information
Overview

scREAD Data ID: AD00105

Species: Human

Region: Prefrontal cortex

Condition: Disease

Braak stage: 3 - 5

Gender: Female

Age: 75-90+ years

Datasets from the same experiment
Dataset information

Number of AD associated cells: 11542

Number of control-like cells: 1644

Number of identified cell types: 6

Dataset source:

Title: Single-cell Transcriptomic Analysis of Alzheimer's Disease

Methodology: Single-nucleus RNA-seq

Protocol: 10x Genomics

GEO/synapse number: syn18485175

Pubmed ID: 31042697

Citation: Mathys, H., Davila-Velderrain, J., Peng, Z. et al. Single-cell transcriptomic analysis of Alzheimer’s disease. Nature 570, 332–337 (2019). 10.1038/s41586-019-1195-2

Cell clustering

Cell type & subcluster:

ARI score: 0.9827172

Gene expression

Point size:

4
Differential expression (DE) / Gene set enrichment

Group:

Find differentially expressed genes in each cell type by comparing it to all of the others.

Cell type of interest:

Log2 fold-change cutoff:

0.5

Adjusted p-value cutoff:

10^-6
10^-5
10^-4
10^-3
0.01
0.05
0.1
1
DE direction:
GJA1 2.31193 0.808 0.012 0.00e+0
SLC1A2 2.30622 0.961 0.154 0.00e+0
GPR98 2.25969 0.92 0.125 0.00e+0
AQP4 2.11009 0.742 0.028 0.00e+0
ATP1A2 2.10408 0.801 0.059 0.00e+0
RNF219-AS1 2.08067 0.696 0.033 0.00e+0
RANBP3L 2.03619 0.668 0.021 0.00e+0
HIF3A 1.98214 0.763 0.045 0.00e+0
GPC5 1.96967 0.955 0.216 0.00e+0
RFX4 1.96139 0.674 0.044 0.00e+0
SLC1A3 1.93519 0.921 0.1 0.00e+0
TPD52L1 1.93295 0.734 0.057 0.00e+0
LINC00499 1.9288 0.554 0.006 0.00e+0
COL5A3 1.9076 0.68 0.045 0.00e+0
FGFR3 1.90278 0.621 0.01 0.00e+0