scREAD A Single-cell RNA-Seq Database for Alzheimer's Disease
General information
Overview

scREAD Data ID: AD00104

Species: Human

Region: Prefrontal cortex

Condition: Disease

Braak stage: 3 - 5

Gender: Male

Age: 75-90+ years

Datasets from the same experiment
Dataset information

Number of AD associated cells: 8283

Number of control-like cells: 1599

Number of identified cell types: 7

Dataset source:

Title: Single-cell Transcriptomic Analysis of Alzheimer's Disease

Methodology: Single-nucleus RNA-seq

Protocol: 10x Genomics

GEO/synapse number: syn18485175

Pubmed ID: 31042697

Citation: Mathys, H., Davila-Velderrain, J., Peng, Z. et al. Single-cell transcriptomic analysis of Alzheimer’s disease. Nature 570, 332–337 (2019). 10.1038/s41586-019-1195-2

Cell clustering

Cell type & subcluster:

ARI score: 0.9888554

Gene expression

Point size:

4
Differential expression (DE) / Gene set enrichment

Group:

Find differentially expressed genes in each cell type by comparing it to all of the others.

Cell type of interest:

Log2 fold-change cutoff:

0.5

Adjusted p-value cutoff:

10^-6
10^-5
10^-4
10^-3
0.01
0.05
0.1
1
DE direction:
SLC1A2 2.47993 0.938 0.14 0.00e+0
GPR98 2.39237 0.885 0.11 0.00e+0
LINC00499 2.29078 0.667 0.005 0.00e+0
RNF219-AS1 2.18326 0.695 0.024 0.00e+0
GPC5 2.12138 0.949 0.19 0.00e+0
RYR3 2.10253 0.846 0.135 0.00e+0
PITPNC1 2.002 0.9 0.198 0.00e+0